Course Description
Raman spectroscopy : Theory – Rayleigh and Raman light scattering – Stokes and anti-Stokes lines – Instrumentation – Raman active vibrations – Polarizability – Raman spectra – Advantages and disadvantages of Raman spectroscopy – Comparison of Raman and IR spectroscopy.
13C and other nuclei NMR: Proton coupling and decoupling 13C spectra - DEPT experiment - NMR of other important nuclei (29Si , 31P , 19F).
Correlation spectroscopy: Theory of 2D-NMR – Pulse sequence for 2D-NMR – Types of 2D-NMR – 1H-1H 2D-NMR (COSY / TOCSY) – 1H-13C 2D-NMR (HSQC / HMQC / HMBC) - Nuclear overhauser effect spectroscopy (NOESY/ROESY) – 13C-13C 2D-NMR (INADEQUATE) – Applications and interpretation of spectra.
Dynamic NMR: Reversible intramolecular processes – Temperature effect – Free energy and rate constant of interconversion - Chemical exchange – Restricted rotation around bonds – Ring conversion.
Mass spectroscopy: Ionization methods (Electron impact EI, Chemical ionization CI, Fast atom bombardment FAB, Electrospray ionization ESI) - Detailed EI fragmentations and rearrangements of various chemical classes –Spectrum interpretation of each ionization method.
Applications of spectroscopy to some organic and biological compounds.
Integration of various kinds of spectra to deduce the chemical structure of organic and biological compounds
Course ID: CHEM 532
| Credit hours | Theory | Practical | Laboratory | Lecture | Studio | Contact hours | Pre-requisite | 3 | 3 | 3 | - |
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